Evaluation of Anti-A/Udorn/307/1972 Antibody Specificity to Influenza A/H3N2 Viruses Using an Evanescent-Field Coupled Waveguide-Mode Sensor
Identifieur interne : 000895 ( Main/Exploration ); précédent : 000894; suivant : 000896Evaluation of Anti-A/Udorn/307/1972 Antibody Specificity to Influenza A/H3N2 Viruses Using an Evanescent-Field Coupled Waveguide-Mode Sensor
Auteurs : Subash C. B. Gopinath [Japon] ; Koichi Awazu [Japon] ; Makoto Fujimaki [Japon] ; Kazufumi Shimizu [Japon]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Discrimination of closely related strains is a key issue, particularly for infectious diseases whose incidence fluctuates according to variations in the season and evolutionary changes. Among infectious diseases, influenza viral infections are a worldwide cause of pandemic disease and mortality. With the emergence of different influenza strains, it is vital to develop a method using antibodies that can differentiate between viral types and subtypes. Ideally, such a system would also be user friendly. In this study, a polyclonal antibody generated against A/Udorn/307/1972 (H3N2) was used as a probe to distinguish between influenza H3N2 viruses based on the interaction between the antibody and hemagglutinin, demonstrating its applicability for viral discrimination. Clear discrimination was demonstrated using an evanescent-field-coupled waveguide-mode sensor, which has appealing characteristics over other methods in the viewpoint of improving the sensitivity, measurement time, portability and usability. Further supporting evidence was obtained using enzyme-linked immunosorbent assays, hemagglutination-inhibition assays, and infectivity neutralization assays. The results obtained indicate that the polyclonal antibody used here is a potential probe for distinguishing influenza viruses and, with the aid of a handheld sensor it could be used for influenza surveillance.
Url:
DOI: 10.1371/journal.pone.0081396
PubMed: 24339924
PubMed Central: 3858306
Affiliations:
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B." last="Gopinath">Subash C. B. Gopinath</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Electronics and Photonics Research Institute, National Institute of Advanced Industrial Science and Technology, Central 5, Tsukuba, Ibaraki, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Electronics and Photonics Research Institute, National Institute of Advanced Industrial Science and Technology, Central 5, Tsukuba, Ibaraki</wicri:regionArea><wicri:noRegion>Ibaraki</wicri:noRegion></affiliation></author><author><name sortKey="Awazu, Koichi" sort="Awazu, Koichi" uniqKey="Awazu K" first="Koichi" last="Awazu">Koichi Awazu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Electronics and Photonics Research Institute, National Institute of Advanced Industrial Science and Technology, Central 5, Tsukuba, Ibaraki, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Electronics and Photonics Research Institute, National Institute of Advanced Industrial Science and Technology, Central 5, Tsukuba, Ibaraki</wicri:regionArea><wicri:noRegion>Ibaraki</wicri:noRegion></affiliation></author><author><name sortKey="Fujimaki, Makoto" sort="Fujimaki, Makoto" uniqKey="Fujimaki M" first="Makoto" last="Fujimaki">Makoto Fujimaki</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Electronics and Photonics Research Institute, National Institute of Advanced Industrial Science and Technology, Central 5, Tsukuba, Ibaraki, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Electronics and Photonics Research Institute, National Institute of Advanced Industrial Science and Technology, Central 5, Tsukuba, Ibaraki</wicri:regionArea><wicri:noRegion>Ibaraki</wicri:noRegion></affiliation></author><author><name sortKey="Shimizu, Kazufumi" sort="Shimizu, Kazufumi" uniqKey="Shimizu K" first="Kazufumi" last="Shimizu">Kazufumi Shimizu</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Open Research Center for Genome and Infectious Disease Control, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Open Research Center for Genome and Infectious Disease Control, Nihon University School of Medicine, Itabashi-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Discrimination of closely related strains is a key issue, particularly for infectious diseases whose incidence fluctuates according to variations in the season and evolutionary changes. Among infectious diseases, influenza viral infections are a worldwide cause of pandemic disease and mortality. With the emergence of different influenza strains, it is vital to develop a method using antibodies that can differentiate between viral types and subtypes. Ideally, such a system would also be user friendly. In this study, a polyclonal antibody generated against A/Udorn/307/1972 (H3N2) was used as a probe to distinguish between influenza H3N2 viruses based on the interaction between the antibody and hemagglutinin, demonstrating its applicability for viral discrimination. Clear discrimination was demonstrated using an evanescent-field-coupled waveguide-mode sensor, which has appealing characteristics over other methods in the viewpoint of improving the sensitivity, measurement time, portability and usability. Further supporting evidence was obtained using enzyme-linked immunosorbent assays, hemagglutination-inhibition assays, and infectivity neutralization assays. The results obtained indicate that the polyclonal antibody used here is a potential probe for distinguishing influenza viruses and, with the aid of a handheld sensor it could be used for influenza surveillance.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Noda, T" uniqKey="Noda T">T Noda</name></author><author><name sortKey="Sagara, H" uniqKey="Sagara H">H Sagara</name></author><author><name sortKey="Yen, A" uniqKey="Yen A">A Yen</name></author><author><name sortKey="Takada, A" uniqKey="Takada A">A Takada</name></author><author><name sortKey="Kida, H" uniqKey="Kida H">H Kida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Rivailler, P" uniqKey="Rivailler P">P Rivailler</name></author><author><name sortKey="Conrardy, C" uniqKey="Conrardy C">C 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C">C Sun</name></author><author><name sortKey="Zhao, K" uniqKey="Zhao K">K Zhao</name></author><author><name sortKey="Chen, K" uniqKey="Chen K">K Chen</name></author><author><name sortKey="He, W" uniqKey="He W">W He</name></author><author><name sortKey="Su, G" uniqKey="Su G">G Su</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Gopinath, Subash C B" sort="Gopinath, Subash C B" uniqKey="Gopinath S" first="Subash C. B." last="Gopinath">Subash C. B. Gopinath</name></noRegion><name sortKey="Awazu, Koichi" sort="Awazu, Koichi" uniqKey="Awazu K" first="Koichi" last="Awazu">Koichi Awazu</name><name sortKey="Fujimaki, Makoto" sort="Fujimaki, Makoto" uniqKey="Fujimaki M" first="Makoto" last="Fujimaki">Makoto Fujimaki</name><name sortKey="Shimizu, Kazufumi" sort="Shimizu, Kazufumi" uniqKey="Shimizu K" first="Kazufumi" last="Shimizu">Kazufumi Shimizu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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